Young women with the FMR1 pre-mutation ie, young women who are carriers of Fragile X,  are at risk of premature ovarian failure.  It is estimated that FXPOI occurs in up to 25% of female carriers of a FMR1 pre-mutation. It can lead to premature menopause, infertility or subfertility, irregular and missed periods, vaginal dryness and insomnia.

Article published in Medical Observer December 2016/January 2017 edition,  by Prof Martin Delatycki, Medical Director of Victorian Clinical Genetics Services, with Jean Hailes for Women’s Health, on behalf of Fragile X Association of Australia, covers this topic.