The March 2016 edition of the Scientific American MIND journal included a comprehensive article about Fragile X syndrome and carriers of Fragile X.

The article discusses the fact that while Fragile X syndrome is quite rare, the Fragile X premutation “is surprisingly common – with a prevalence of around 1 in 150 women, and one in 450 men.”

It goes on to note that “In the past two decades researchers have begin to discover that the FX premutation is associated with certain health outcomes, including infertility in women and a neurodegenerative condition known as Fragile X-associated Tremor Ataxia syndrome”, first identified by Professors Randi and Paul Hagerman.

The article includes a case study of one family’s story, with several generations of that family impacted by Fragile X:  Fragile X syndrome, FXPOI and FXTAS.

The article refers to the work of Dr Randi Hagerman, Ms Louise Gane, Dr Danuta Loesch from Australia, and others researching in the field.

http://www.scientificamerican.com/article/the-x-factor-in-infertility-and-neurological-health/